Serums
Creams & Moisturizers
Eye Care
Cleansers & Toners
Masks & Treatments
Complexion & Glow
Body & Bath
Retinol Serum — Clinical Results
Clinical Results
Retinol Serum — The Evidence
Retinol is the most-studied anti-ageing ingredient in dermatology. Here is what the peer-reviewed research shows for topical retinol — the active this serum is built on.
The ingredient evidence
Retinol (vitamin A)
Peer-reviewedRetinol converts to retinoic acid in the skin, where it boosts collagen synthesis and inhibits the matrix metalloproteinases that break collagen down — the mechanism behind its effect on lines, texture and tone. In a one-year, double-blind, vehicle-controlled study of stabilised retinol, the signs of photoageing improved steadily and did not plateau; a separate 24-week randomized controlled trial of 0.4% retinol significantly reduced fine wrinkles, with new collagen confirmed on skin biopsy.
| Clinical result (stabilised retinol 0.1%) | Figure |
|---|---|
| Improvement in crow’s-feet fine lines (52 weeks) | +44% |
| Improvement in mottled pigmentation (52 weeks) | +84% |
| Visible improvement in photoageing signs | from wk 4 |
Method: Peer-reviewed clinical literature on topical retinol — a one-year, double-blind, vehicle-controlled trial of 0.1% stabilised retinol, and a 24-week RCT of 0.4% retinol with biopsy-confirmed collagen. Evidence for the ingredient at its studied dose, not the finished serum. Use at night, introduce gradually, and always apply SPF the next morning.
Sources: peer-reviewed topical-retinol literature (one-year stabilised-retinol vehicle-controlled trial; Kafi et al., 24-week RCT). Ingredient-level evidence at studied doses, not the finished product. Individual results may vary.