R+R Longevity Serum — Clinical Results
Clinical Results
R+R Longevity Serum — Renovage® + Retinol
A next-generation serum pairing Renovage®, a cellular-longevity active, with a time-release retinol — the gold standard in anti-ageing — to target fine lines, wrinkles, texture, pores and uneven tone.
The ingredient evidence
Renovage® (teprenone)
At its studied doseA cellular-longevity active that supports the skin as it ages — improving hydration, firmness and tone while softening the look of lines, spots and enlarged pores.
| Clinical result | Figure |
|---|---|
| Appearance of main lines (6 months) | −47% |
| Age spots (6 months) | −42% |
| Pore dilation (6 months) | −26% |
| Skin hydration (3 months) | +38% |
| Skin tone / firmness / elasticity (1 month) | +15% / +12% / +11% |
Method: Supplier clinical study of 3% Renovage on 24 volunteers (mean age 58), measured over 1–6 months. Supplier study of the ingredient; not conducted on the finished Osmotics product.
Time-release retinol
Peer-reviewedRetinol is the most-studied anti-ageing ingredient. It converts to retinoic acid in the skin, boosting collagen synthesis and inhibiting the matrix metalloproteinases that break collagen down. In a 24-week randomized controlled trial, 0.4% retinol significantly reduced fine wrinkles in naturally aged skin, with biopsy-confirmed new collagen. This serum uses a time-release delivery to reduce the irritation retinol can cause.
| Peer-reviewed finding | Result |
|---|---|
| Improvement in fine-wrinkle appearance over 12–24 weeks (review range) | ~30–50% |
Method: Peer-reviewed clinical literature on topical retinol (e.g., Kafi et al., 24-week RCT). Evidence for the ingredient; the finished serum’s retinol concentration is proprietary. Introduce gradually and use SPF each morning.
Sources: Sederma (Renovage / teprenone) supplier clinical dossier; peer-reviewed topical-retinol literature. Ingredient-level evidence at studied doses, not the finished product. Individual results may vary.









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