Eyeseryl (Acetyl Tetrapeptide-5): The Complete Guide

Eyeseryl® is a peptide developed specifically for one of the most stubborn eye concerns: under-eye puffiness and bags. This guide explains what it is and how it works.

What is Eyeseryl®?

Eyeseryl® (INCI: acetyl tetrapeptide-5) is a small anti-puffiness peptide. It’s studied to help the look of under-eye bags by supporting healthy fluid balance and the resilience of the delicate skin and vessels beneath the eye — two of the drivers behind morning puffiness.

What does it do for skin?

• De-puffs the look of bags — targets fluid-related under-eye puffiness.
• Supports the eye area — helps the fragile skin look smoother and more rested.

Where we use it

We carry Eyeseryl® at its clinically studied dose in Under Eye Rejuvenator, alongside the Haloxyl™ complex for dark circles. In the ingredient’s own supplier study, a formula containing it at its studied level visibly reduced under-eye puffiness in most volunteers over 60 days. Read our dark circles guide or the peptides guide. Figures refer to the ingredient at its studied dose, not the finished product. Individual results vary.

Frequently asked questions

What is Eyeseryl (acetyl tetrapeptide-5) used for?

It’s a peptide used to reduce the appearance of under-eye puffiness and bags.

Does it help dark circles?

Its main role is puffiness; for the discoloration side of dark circles it’s usually paired with brightening or vascular-targeting actives like Haloxyl™.

How long does it take to work?

Supplier studies measured visible change over roughly two months of consistent use. Individual results vary.