Coenzyme Q10 (Ubiquinone): The Complete Guide

Written by the Osmotics team · Reviewed by Elena Hart, MD, dermatologist · Last updated

The short answer

Coenzyme Q10 (ubiquinone) is an antioxidant naturally found in skin that supports cellular energy and helps defend against ageing from oxidative stress.

Quick answer: Coenzyme Q10 (ubiquinone) is an antioxidant your skin cells use for energy. Levels fall with age, so topping it up helps defend against environmental damage and supports the skin’s renewal energy — for a more resilient, energised-looking complexion.

What is Coenzyme Q10?

Coenzyme Q10 (CoQ10, or ubiquinone) is a fat-soluble antioxidant found naturally in every cell, where it plays a central role in producing cellular energy. Because skin cells rely on that energy to renew and repair, and CoQ10 levels decline with age, it’s a popular anti-ageing antioxidant.

What does it do for skin?

  • Antioxidant defence — neutralises free radicals from UV and pollution.
  • Supports cellular energy — helps power the skin’s natural renewal.
  • Energises a tired-looking complexion — for a more resilient, healthy appearance.

How to use it

CoQ10 comes formulated into antioxidant serums and moisturisers, for daily use — particularly useful in the morning under SPF. It pairs well with vitamins C and E and other antioxidants.

Is it safe?

As a gentle, naturally occurring antioxidant it’s generally very well tolerated. This guide is general education, not medical advice; individual results vary.

Explore our other antioxidants in the Ingredient Glossary, or find your match with the skin quiz.

Frequently asked questions

What does CoQ10 do for skin?

It’s an antioxidant that defends against free radicals and supports the cellular energy skin uses to renew and repair.

Why does CoQ10 matter as we age?

Natural CoQ10 levels fall with age, so replenishing it topically helps support the skin’s antioxidant defence and renewal energy.

Can I use CoQ10 with other antioxidants?

Yes — it pairs well with vitamins C and E and other antioxidants for broader protection.

When should I use it?

Morning under SPF is ideal for daytime defence, though it works any time.

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References

  1. Hoppe U, Bergemann J, Diembeck W, et al. Coenzyme Q10, a cutaneous antioxidant and energizer. Biofactors. 1999;9(2–4):371–378.
  2. Knott A, Achterberg V, Smuda C, et al. Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects. Biofactors. 2015;41(6):383–390.

This guide describes the appearance of skin and is general education, not medical advice; individual results may vary.